Anti-ZAP70 Antibody BHA10205860

Mfr.No.	7535-MSM3-P1ABX
Alternative Names	Selective T cell defect ; SRK ; STD ; Syk-related tyrosine kinase ; Tyrosine-protein kinase ZAP-70 ; TZK ; Zeta chain associated protein kinase 70kDa
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	2q12
Clonality	Monoclonal
Description	ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.ĀControl of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.ĀAnti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
Host	Mouse
Immunogen	Recombinant full-length human ZAP70 protein (ZAP70/528); Recombinant ZAP-70 protein including residues 1-254 and encompassing SH2 domains of human ZAP70 (2F3.2)
Positive Control	Jurkat cells. Tonsil or lymph node.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P43403
Uniprot	234569
Gene Id	7535

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205860	7535-MSM3-P1ABX	100µg	$393.20		Add to Cart

Anti-ZAP70 Antibody BHA10205860

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