Anti-Wilm's Tumor 1 (WT1) Antibody BHA10205814

Mfr.No.	7490-MSM1X-P1ABX
Alternative Names	WT1 ; AWT1 ; FWT1 ; GUD ; NPHS4 ; WAGR ; Wilms tumor 1
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	11p13
Clonality	Monoclonal
Description	Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors.ĀWT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.
Host	Mouse
Immunogen	Recombinant protein corresponding to residues 1-181 of human WT1.
Positive Control	K562 cells. Wilm s Tumor, mesothelioma or fetal kidney.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO

Swissprot	P19544
Uniprot	591980
Gene Id	7490

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205814	7490-MSM1X-P1ABX	100µg	$393.20		Add to Cart

Anti-Wilm's Tumor 1 (WT1) Antibody BHA10205814

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