Anti-Tyrosinase Antibody BHA10205596

Mfr.No.	7299-MSM1X-P1ABX
Alternative Names	ATN ; CMM8 ; LB24-AB ; Monophenol monooxygenase ; OCA1 ; OCA1A ; Oculocutaneous albinism IA ; SHEP3 ; SK29-AB ; Tumor rejection antigen AB
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	11q14.3
Clonality	Monoclonal
Description	Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Host	Mouse
Immunogen	Recombinant tyrosinase protein
Positive Control	SK-MEL-13, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells or Melanoma.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P14679
Uniprot	503555
Gene Id	7299

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, or 10mM Citrate buffer, pH6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205596	7299-MSM1X-P1ABX	100µg	$393.20		Add to Cart

Anti-Tyrosinase Antibody BHA10205596

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