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Home / Primary Antibodies / IHC Antibodies

Anti-p53 Tumor Suppressor Protein Antibody BHA10205466

SKU : BHA10205466

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NeoBiotechnologies, Inc.

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Mfr.No.	7157-MSM4-P0
Alternative Names	Antigen NY-CO-13 ; BCC7 ; Cellular Tumor Antigen p53 ; LFS1 ; TP53 ; Transformation Related Protein 53 (TRP53) ; Tumor Protein p53 ; Tumor Suppressor p53
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	17p13.1
Clonality	Monoclonal
Description	PAb122 binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. p53 Is the most commonly mutated gene in spontaneously occurring human cancers. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation.
Host	Mouse
Immunogen	SV40-transformed mouse B4 cells
Positive Control	MDA-MB-231 or A431 Cells. Breast or Colon carcinoma
Reactivity	Human, Monkey, Dog, Mouse, Rat, Hamster
Recombinant	FALSE
Regulatory	RUO

Swissprot	P04637
Uniprot	654481
Gene Id	7157

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	200µg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml

Applications

FACS, IF, IHC-F

Description

Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.5-1.0μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205466	7157-MSM4-P0	20µg	$204.67		Add to Cart
BHA10205466	7157-MSM4-P0	100µg	$393.20		Add to Cart

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