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Home / Primary Antibodies / Monoclonal Antibodies

Anti-TNF-alpha (Tumor Necrosis Factor alpha) Antibody BHA10205406

SKU : BHA10205406

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NeoBiotechnologies, Inc.

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Mfr.No.	7124-MSM7-P0
Alternative Names	APC1 ; Cachectin ; Differentiation inducing factor (DIF) ; Macrophage cytotoxic factor (MCF) ; Necrosin ; TNF alpha ; TNF Macrophage Derived ; TNF Monocyte Derived ; TNF Superfamily Member 2 ; TNFA
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic, Extracellular(secreted)
Chromosome Location	6p21.33
Clonality	Monoclonal
Description	This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule, or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Host	Mouse
Immunogen	Recombinant human TNF-alpha
Isotype	IgM Kappa
Positive Control	HeLa, HL-60, or A431 cells. Macrophages in lymph node or Tonsil
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01375
Uniprot	241570
Gene Id	7124

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide.
Concentration	200µg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml

Applications

FACS, IF

Description

Neutralization (Order Ab without BSA & Azide); Optimal dilution for a specific application should be determined., FACS ; IF

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205406	7124-MSM7-P0	20µg	$204.67		Add to Cart
BHA10205406	7124-MSM7-P0	100µg	$393.20		Add to Cart

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