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Home / Primary Antibodies / Flow Cytometry (FACS)

Anti-BRCA1 Antibody BHA10205102

SKU : BHA10205102

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NeoBiotechnologies, Inc.

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Mfr.No.	672-MSM2-P1ABX
Alternative Names	BRCA1 ; Breast and ovarian cancer susceptibility protein 1 ; Breast Cancer 1 Early Onset ; Breast cancer type 1 susceptibility protein ; BROVCA1 ; IRIS ; PNCA4 ; PPP1R53 ; Protein phosphatase 1 regulatory subunit 53 ; PSCP
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic, Nuclear
Chromosome Location	17q21
Clonality	Monoclonal
Description	This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Host	Mouse
Immunogen	Recombinant human BRCA1 protein fragment (aa445-620) (exact sequence is proprietary)
Isotype	IgG1
Positive Control	A431 or HeLa Cells. Breast, Ovarian or Renal Cell Carcinoma
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P38398
Uniprot	194143
Gene Id	672

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

ELISA, FACS, IF

Description

Optimal dilution for a specific application should be determined., ELISA ; FACS ; IF

Dilution

ELISA	For coating, order Ab without BSA
FACS	0.5-1μg/million cells
IF	1-2μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205102	672-MSM2-P1ABX	100µg	$393.20		Add to Cart

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