Anti-Transglutaminase II (TGM2) Antibody BHA10205287

Mfr.No.	7052-MSM1X-P1ABX
Alternative Names	G alpha h ; G[a]h ; GNAH ; Guanine nucleotide binding protein H polypeptide ; Protein-glutamine gamma-glutamyltransferase 2 ; TG(C) ; TG2 ; TGase C ; TGase H ; TGase-2
Categories	Primary Antibodies
Cellular Localization	Cell Surface, Cytoplasmic
Chromosome Location	20q12
Clonality	Monoclonal
Description	Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Host	Mouse
Immunogen	Recombinant full-length human TGM2 protein
Isotype	IgG2a Kappa
Positive Control	HUVEC Cells. Endothelial cells in placenta, liver, brain, or breast carcinoma. Smooth muscle cells of any origin (e.g. intestine)
Reactivity	Human, Monkey, Rabbit, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	P21980
Uniprot	517033
Gene Id	7052

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.5-1μg/ml, 30 min at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205287	7052-MSM1X-P1ABX	100µg	$393.20		Add to Cart

Anti-Transglutaminase II (TGM2) Antibody BHA10205287

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