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Home / Primary Antibodies / Monoclonal Antibodies

Anti-TIA1 (T-Cell-Restricted Intracellular Antigen-1) Antibody BHA10205310

SKU : BHA10205310

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NeoBiotechnologies, Inc.

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Mfr.No.	7072-MSM1-P0
Alternative Names	Cytotoxic granule associated RNA binding protein 1 ; mTIA-1 ; Nucleolysin TIA1 isoform p40 ; p40-TIA-1 ; RNA binding protein TIA1 ; T-cell-restricted intracellular antigen-1 (TIA1) ; TIA-1 ; TIA1 ; TIA1 cytotoxic granule associated RNA binding protein ; TIAL1
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	2p13
Clonality	Monoclonal
Description	TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kDa protein thought to be derived from the carboxyl terminus of the 40kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
Host	Mouse
Immunogen	Recombinant human TIA1 fragment of 102 amino acid residues (aa279-380) (exact sequence is proprietary)
Isotype	IgG2b
Positive Control	HepG2, PC3 and HeLa cells. Tonsil.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P31483
Uniprot	413123
Gene Id	7072

Buffer	200μg/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Concentration	200µg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml

Applications

FACS, IF, WB

Description

Optimal dilution for a specific application should be determined., FACS ; IF ; WB

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
WB	1-2μg/ml for 60 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205310	7072-MSM1-P0	20µg	$204.67		Add to Cart
BHA10205310	7072-MSM1-P0	100µg	$393.20		Add to Cart

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