Anti-SOX10 Antibody BHA10205019

Mfr.No.	6663-MSM3-P1ABX
Alternative Names	DOM ; PCWH ; SOX10 ; SRY (sex determining region Y) box 10 ; SRY box containing gene 10 ; SRY related HMG box gene 10 ; Waardenburg syndrome type 2E (WS2E) ; WS4 ; Waardenburg syndrome type 4C (WS4C)
Categories	Primary Antibodies
Cellular Localization	Nuclear
Clonality	Monoclonal
Description	Recognizes a protein of ~55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
Host	Mouse
Immunogen	Recombinant human SOX10 protein fragment (aa115-269) (exact sequence is proprietary)
Isotype	IgG2b Kappa
Positive Control	HepG2 cells. Melanomas, breast carcinomas, gliomas.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO

Swissprot	P56693 (Human)
Uniprot	376984 (Human)Human Gene SymbolSOX10Hu Chromosome Location22q13.1
Gene Id	6663 (Human)

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	1-2μg/ml
WB	0.5-1.0μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205019	6663-MSM3-P1ABX	100µg	$393.20		Add to Cart

Anti-SOX10 Antibody BHA10205019

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