Anti-pS2 / pNR-2 / Trefoil Factor 1 (Estrogen-Regulated Protein) Antibody BHA10205143

Mfr.No.	7031-MSM1X-P1ABX
Alternative Names	BCEI ; Breast Cancer Estrogen Inducible Protein ; Gastrointestinal Trefoil Protein ; Gastrointestinal trefoil protein pS2 ; HP1A ; HPS2 ; pNR2 ; TFF1 ; Trefoil Factor 1
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	16p11.2
Clonality	Monoclonal
Description	It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Host	Mouse
Immunogen	Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2.
Isotype	IgG1 Kappa
Positive Control	Spent medium of MCF-7 cells, treated with estrogen. Normal stomach. About 60% of breast carcinomas are positive for pS2, especially those that are also positive for estrogen and/or progesterone receptor.
Reactivity	Human, Cynomolgus Monkey
Recombinant	FALSE
Regulatory	RUO

Swissprot	P04155
Uniprot	162807
Gene Id	7031

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.5-1.0μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205143	7031-MSM1X-P1ABX	100µg	$393.20		Add to Cart

Anti-pS2 / pNR-2 / Trefoil Factor 1 (Estrogen-Regulated Protein) Antibody BHA10205143

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