Anti-SUMO-2 Antibody BHA10204969

Mfr.No.	6613-MSM2-P1ABX
Alternative Names	HSMT3 ; Sentrin 2 ; Small ubiquitin like modifier 2 ; Small ubiquitin like modifier protein 3 ; SMT3A ; SMT3B ; SMT3 homolog 1 (SMT3H1) ; SMT3 homolog 2 (SMT3H2) ; SMT3 homolog ; SMT3 suppressor of mif two 3 homolog 1
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	17q25.1
Clonality	Monoclonal
Description	The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer s disease.
Host	Mouse
Immunogen	Recombinant human SUMO2 protein
Isotype	IgG1 Kappa
Positive Control	HeLa cells or breast carcinoma
Reactivity	Human, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	P55854
Uniprot	474005
Gene Id	6613

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution