Anti-Spectrin beta III (SPTBN2) Antibody BHA10205092

Mfr.No.	6712-MSM4-P1ABX
Alternative Names	Beta III spectrin ; SCA5 ; Spectrin beta chain brain 2 ; Spectrin beta non-erythrocytic 2 ; Spectrin non-erythroid beta chain 2 ; Spinocerebellar ataxia 5 ; SPTBN2
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	11q13.2
Clonality	Monoclonal
Description	Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II), four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin α and spectrin β are present in erythrocytes, whereas spectrin α II (also designated fodrin α) and spectrin β I (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin β III is highly homologous to both spectrin β I and spectrin β II. Spectrin β III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites.
Host	Mouse
Immunogen	Recombinant human SPTBN2 fragment (aa356-475) (exact sequence is proprietary)
Isotype	IgG1
Positive Control	HeLa cells. Pancreas or Liver.
Reactivity	Human, Rat, Mouse
Recombinant	FALSE
Regulatory	RUO

Swissprot	O15020
Uniprot	26915
Gene Id	6712

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	0.5-1μg/ml
WB	0.5-1.0μg/ml
IHC-F	0.5-1.0μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205092	6712-MSM4-P1ABX	100µg	$393.20		Add to Cart

Anti-Spectrin beta III (SPTBN2) Antibody BHA10205092

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