It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa (Workshop IV). This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
Host
Mouse
Immunogen
KG1 acute myeloid leukemia cell line
Isotype
IgG1 Kappa
Positive Control
CCRF-CEM, Jurkat or K-562. Human placenta or breast carcinoma.
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P02786
Uniprot
529618
Gene Id
7037
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, WB
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; WB
Dilution
FACS
0.5-1μg/million cells in 0.1ml
IF
1-2μg/ml
WB
0.5-1.0μg/ml
Reviews of Anti-CD71 / Transferrin Receptor (TFRC) Antibody BHA10205160