Anti-CD284 (Toll-Like Receptor 4) Antibody BHA10205361

Mfr.No.	7099-MSM1-P1ABX
Alternative Names	ARMD10 ; CD284 ; hToll ; TLR4 ; TOLL ; Toll Endotoxin Hyporesponsiveness ; Toll-like receptor 4
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	9q33.1
Clonality	Monoclonal
Description	This MAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
Host	Mouse
Immunogen	Recombinant human TLR4 protein
Isotype	IgG2a Kappa
Positive Control	HeLa, PC12, human peripheral blood cells. Dendritic cells, macrophage and monocytes in tonsil; placenta and adrenal.
Reactivity	Human, Monkey, Pig, Dog, Rat, Guinea pig
Recombinant	FALSE
Regulatory	RUO

Swissprot	O00206
Uniprot	174312
Gene Id	7099

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

Functional Studies (Order Ab without Azide); (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10205361	7099-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-CD284 (Toll-Like Receptor 4) Antibody BHA10205361

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