Anti-Calprotectin Antibody BHA10204828

Mfr.No.	6280-MSM4-P1ABX
Alternative Names	S100-A9 ; MRP14 ; calgranulin-B ; calprotectin L1H subunit ; leukocyte L1 complex heavy chain ; migration inhibitory factor-related protein 14 ; S100 calcium-binding protein A9 (calgranulin B)
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	1q21
Clonality	Monoclonal
Description	Recognizes the L1 or Calprotectin molecule, an intra-cytoplasmic antigen comprising of a 12kDa alpha chain and a 14kDa beta chain. Calprotectin comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. Calprotectin has antibacterial, antifungal, immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity, like inflammatory bowel disease. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore calprotectin is also detectable in feces. Elevated levels of calprotectin have been observed in body fluids such as plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions.ĀThis MAb reacts with neutrophils, monocytes, macrophages, and squamous mucosal epithelia and is important for identifying macrophages in tissue sections.
Host	Mouse
Immunogen	Recombinant human Calprotectin protein
Isotype	IgM Kappa
Positive Control	Tonsil, lymph node, or spleen
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P06702
Uniprot	112405
Gene Id	6280

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10204828	6280-MSM4-P1ABX	100µg	$393.20		Add to Cart

Anti-Calprotectin Antibody BHA10204828

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