B-cell lymphoma 5 protein ; B-Cell Lymphoma 6 Protein ; BCL5 ; BCL6 ; BCL6A ; cys his2 zinc finger transcription factor ; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3) ; Zinc finger and BTB domain-containing protein 27 (ZBTB27) ; Zinc Finger Protein 51 (ZNF51) ; zinc finger transcription factor BCL6S
Categories
Primary Antibodies
Cellular Localization
Nuclear
Chromosome Location
3q27.3
Clonality
Monoclonal
Description
Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Host
Mouse
Immunogen
Recombinant human bcl-6 protein fragment (aa256-389) (exact sequence is proprietary)
Isotype
IgG1 Kappa
Positive Control
Raji or Ramos cells. Tonsil
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P41182
Uniprot
478588
Gene Id
604
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, WB
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; WB