B6P ; Band 6 protein ; PKP1 ; Plakophilin-1 (ectodermal dysplasia/skin fragility syndrome)
Categories
Primary Antibodies
Cellular Localization
Cell Surface, Nuclear
Chromosome Location
1q32
Clonality
Monoclonal
Description
Recognizes a protein of 75kDa, identified as Plakophilin-1. Its epitope maps between aa 1-27 human Plakophilin-1. Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.
Host
Mouse
Immunogen
N-terminus of human Plakophilin-1 protein (exact sequence is proprietary)
Isotype
IgG1
Positive Control
HaCat Cells.
Reactivity
Human, Mouse
Recombinant
FALSE
Regulatory
RUO
Swissprot
Q13835
Uniprot
497350
Gene Id
5317
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, WB
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; WB
Dilution
FACS
0.5-1μg/million cells
IF
1-2μg/ml
WB
0.5-1.0μg/ml
Reviews of Anti-Plakophilin-1 (PKP1) Antibody BHA10204115