Adrenocorticotropin ; alpha or beta or gamma Melanocyte Stimulating Hormone (MSH) or Melanotropin ; beta-Endorphin ; beta or gamma Lipotropin (LPH) ; CLIP ; Met Enkephalin ; POC ; POMC
Categories
Primary Antibodies
Cellular Localization
Cytoplasmic
Chromosome Location
2p23.3
Clonality
Monoclonal
Description
ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to CLIP (aa25-39 of ACTH); does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
Host
Mouse
Immunogen
Synthetic peptide corresponding to aa25-39 of human ACTH (NGAEDESAEAFPLEF)
Isotype
IgG1
Positive Control
Normal pituitary gland or pituitary tumor
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P01189
Uniprot
1897
Gene Id
5443
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
ELISA, FACS, IF
Description
Optimal dilution for a specific application should be determined., ELISA ; FACS ; IF
Dilution
ELISA
For coating, order Ab without BSA
FACS
0.5-1μg/million cells in 0.1ml
IF
1-2μg/ml
Reviews of Anti-ACTH (Adrenocorticotrophic Hormone) (C-Terminus) Antibody BHA10204223