Anti-NKX2.2 Antibody BHA10203838

Mfr.No.	4821-MSM1-P1ABX
Alternative Names	Homeobox protein NK-2 homolog B ; NK2 transcription factor like protein B ; NK2 transcription factor related locus 2 ; NKX22 ; Nkx2b ; tinman
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	20p11.22
Clonality	Monoclonal
Description	Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Host	Mouse
Immunogen	Human full-length recombinant NKX2.2 protein
Isotype	IgG2b Kappa
Positive Control	Pancreas or Ewing s sarcoma
Reactivity	Human, Mouse, Rat, Chicken
Recombinant	FALSE
Regulatory	RUO

Swissprot	O95096
Uniprot	516922
Gene Id	4821

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution