Anti-NGF-Receptor (p75) / CD271 Antibody BHA10203814

Mfr.No.	4804-MSM1-P1ABX
Alternative Names	CD271 ; Gp80-LNGFR ; Low affinity nerve growth factor receptor ; Low affinity neurotrophin receptor p75NTR ; Nerve growth factor receptor (NGFR) ; TNFR superfamily member 16 ; p75 ICD ; p75 Neurotrophin receptor ; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16)
Categories	Primary Antibodies
Cellular Localization	Cell Surface, Cytoplasmic
Chromosome Location	17q21-22
Clonality	Monoclonal
Description	It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
Host	Mouse
Immunogen	NGFR from A875 melanoma cells
Isotype	IgG1 Kappa
Positive Control	Neuronal axons, Schwann cells, and perineural cells of peripheral nerves, or tumors of nerve sheath differentiation e.g. Schwannoma, Neurofibroma. Soma and axons of sensory neurons, and ganglionic satellite cells. Melanomas.
Reactivity	Human, Monkey, Baboon, Cat, Rabbit, ferret
Recombinant	FALSE
Regulatory	RUO

Swissprot	P08138
Uniprot	415768; 681726
Gene Id	4804

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10203814	4804-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-NGF-Receptor (p75) / CD271 Antibody BHA10203814

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