Apomucin Major Airway Glycoprotein ; Mucin 5 subtype AC tracheobronchial ; Mucin 5 Subtypes A And C ; Mucin 5AC oligomeric mucus/gel forming ; Tracheobronchial Mucin (TBM)
Categories
Primary Antibodies
Cellular Localization
Cytoplasmic
Chromosome Location
11p15.5
Clonality
Monoclonal
Description
This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC).ĀIts epitope is located in the C-terminal cysteine rich part of the peptide core of MUC5AC. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
Host
Mouse
Immunogen
M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient
Isotype
IgG1 Kappa
Positive Control
Stomach
Reactivity
Human, Monkey, Rabbit, Cat, Mouse, Rat, Pig, Hedgehog, Chicken
Recombinant
FALSE
Regulatory
RUO
Swissprot
P98088
Uniprot
534332
Gene Id
4586
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, IHC-F
Description
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F
Dilution
FACS
0.5-1μg/million cells in 0.1ml
IF
1-2μg/ml
IHC-F
1-2μg/ml for 30 minutes at RT
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Reviews of Anti-MUC5AC (Mucin 5AC / Gastric Mucin) Antibody BHA10203499