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Home / Primary Antibodies / Flow Cytometry (FACS)

Anti-CD46 (Membrane Cofactor Protein) Antibody BHA10203221

SKU : BHA10203221

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NeoBiotechnologies, Inc.

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Mfr.No.	4179-MSM1-P1ABX
Alternative Names	AHUS2 ; CD46 antigen complement regulatory protein ; Complement membrane cofactor protein ; MCP ; Measles virus receptor ; Membrane cofactor protein ; MIC10 ; TLX ; Trophoblast leucocyte common antigen
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	1q32.2
Clonality	Monoclonal
Description	CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Host	Mouse
Immunogen	Recombinant human CD46 protein
Isotype	IgG1 Kappa
Positive Control	HeLa, K-562 or MOLT-4 cells. Kidney
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P15529
Uniprot	510402
Gene Id	4179

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF

Description

Functional Studies (Order Ab without Azide); Optimal dilution for a specific application should be determined., FACS ; IF

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10203221	4179-MSM1-P1ABX	100µg	$393.20		Add to Cart

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