Anti-LAIR-1 (Leukocyte-Associated Ig-Like Receptor 1) / CD305 Antibody BHA10202984

Mfr.No.	3903-MSM1-P1ABX
Alternative Names	CD305 ; D7Bwg0421e ; hLAIR1 ; LAIR-1 ; LAIR1 ; Leukocyte associated Ig like receptor 1 ; Leukocyte-associated immunoglobulin-like receptor 1
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	19q13.4
Clonality	Monoclonal
Description	Recognizes a single protein of 40kDa, identified as the CD305 (LAIR1). It is an inhibitory receptor, expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells.ĀThis MAb is expressed on CD34 positive hematopoietic progenitors. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants.Ā This MAb is identical to LAIR-1, based on the fact that it not only precipitated a protein of 40kDa but it also binds specifically to LAIR-1 cDNA transfected COS7 cells as well as recognizes LAIR-1 fusion protein in ELISA. LAIR-1 expresses on hematopoietic progenitor, implicating its role in the regulation of hematopoiesis at early stage.
Host	Mouse
Immunogen	Human Lymphocytes and Large Granular Lymphocytes (LGL)
Isotype	IgG2 Kappa
Positive Control	Human peripheral blood mononuclear cells or natural killer cells.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q6GTX8
Uniprot	572535
Gene Id	3903

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF

Description

Inhibits NK & ALK Cell Mediated Cytolysis (Use Ab without BSA & Azide); nhibits TNF-alpha secretion of NK cells (Use Ab without BSA & Azide); nduces Colony Formation of Human Bone Marrow Cells (Use Ab without BSA & Azide); Optimal dilution for a specific application should be determined., FACS ; IF

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202984	3903-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-LAIR-1 (Leukocyte-Associated Ig-Like Receptor 1) / CD305 Antibody BHA10202984

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