CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin �M combines with the Integrin ?2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin �M/?2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b and CD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.
Host
Mouse
Immunogen
Recombinant human CD11b protein
Isotype
IgG2b Kappa
Positive Control
Human monocytes & granulocytes. Human lymph nodes and tonsils.
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P11215
Uniprot
172631
Gene Id
3684
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, Func
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; Func
Dilution
FACS
0.5-1μg/million cells in 0.1ml
IF
0.5-1μg/ml
Func
Order Ab without BSA & Azide
Reviews of Anti-CD11b / MAC-1 Antibody BHA10202467