Anti-Cytokeratin 8 (KRT8) Antibody BHA10202731

Mfr.No.	3856-MSM6-P1ABX
Alternative Names	CARD2 ; CK8 ; CYK8 ; CYKER ; Cytokeratin Endo A ; DreK8 ; EndoA ; K2C8 ; K8 ; Keratin 8
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	12q13.13
Clonality	Monoclonal
Description	Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (�ring-like, perinuclear�) from ductal (�peripheral-predominant�) carcinoma of the breast.
Host	Mouse
Immunogen	Cytoskeletal preparation from HeLa cells
Isotype	IgG1 Kappa
Positive Control	MCF-7 or A431 cells. Skin, Colon, lung or breast carcinoma
Reactivity	Human, Sheep, Rabbit, Cow, Pig
Recombinant	FALSE
Regulatory	RUO

Swissprot	P05787
Uniprot	533782; 708445
Gene Id	3856

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml
IHC-F	0.5-1.0μg/ml for 30 min at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202731	3856-MSM6-P1ABX	100µg	$393.20		Add to Cart

Anti-Cytokeratin 8 (KRT8) Antibody BHA10202731

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