Anti-Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Antibody BHA10202620

Mfr.No.	3853-MSM1X-P1ABX
Alternative Names	CK6A ; CK6B ; CK6C ; CK6D ; CK6E ; Keratin Type II Cytoskeletal 6A ; Keratin Type II Cytoskeletal 6B ; Keratin Type II Cytoskeletal 6C ; Keratin Type II Cytoskeletal 6D ; Keratin Type II Cytoskeletal 6E
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	12q13.13
Clonality	Monoclonal
Description	This MAb recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.
Host	Mouse
Immunogen	A synthetic peptide of 11 amino acids (GSSTIKYTTTS) from C-terminus of human keratin 6
Isotype	IgG2a Kappa
Positive Control	Suprabasal cells of the outer hair follicle root sheath in skin. Basal cell carcinoma
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO

Swissprot	P02538; P04259; P48668
Uniprot	700779
Gene Id	3853;3854;286887

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.1-0.2μg/ml for 30 min at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202620	3853-MSM1X-P1ABX	100µg	$393.20		Add to Cart

Anti-Cytokeratin 6 (KRT6) (Hyperproliferation-Related Keratin) Antibody BHA10202620

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