Arginase 1 ; ARG1 ; liver-type arginase ; type I arginase
Antigen
Arginase 1
Categories
Primary Antibodies
Cellular Localization
Cytoplasmic
Chromosome Location
6q23
Clonality
Monoclonal
Conjugate
Unconjugated
Description
Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.
Host
Mouse
Immunogen
Recombinant fragment (87 Amino acid residues around aa 1-150) of human ARG1 protein
Isotype
IgG
Positive Control
293T cells. Hepatocellular Carcinoma (HCC).
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P05089
Uniprot
440934
Gene Id
383
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, IHC-F
Description
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F