AIS ; Dihydrotestosterone receptor (DHTR) ; HUMARA ; HYSP1 ; Kennedy disease (KD) ; Nuclear receptor subfamily 3 group C member 4 (NR3C4) ; SMAX1 ; Spinal and bulbar muscular atrophy (SBMA) ; Testicular Feminization (TFM)
Categories
Primary Antibodies
Cellular Localization
Nuclear
Chromosome Location
Xq12
Clonality
Monoclonal
Description
Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This MAb is superb for staining of formalin/paraffin tissues.
Host
Mouse
Immunogen
A synthetic peptide, aa 302-318 (STEDTAEYSPFKGGYTK) of human AR
Isotype
IgG1 Kappa
Positive Control
LNCap cells or Prostate carcinoma
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P10275
Uniprot
496240
Gene Id
367
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, IHC-F
Description
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F
Dilution
FACS
0.5-1μg/million cells
IF
0.5-1μg/ml
IHC-F
0.5-1μg/ml for 30 minutes at RT
Reviews of Anti-Androgen Receptor Antibody BHA10202432