Anti-IgM (Immunoglobulin Mu Heavy Chain) Antibody BHA10202181

Mfr.No.	3507-MSM1X-P1ABX
Alternative Names	AGM1 ; IGHM ; Constant Region of Heavy Chain of IgM ; Ig Mu Chain C Region
Categories	Primary Antibodies
Cellular Localization	Cell Surface, Cytoplasmic (Secreted)
Chromosome Location	14q32.33
Clonality	Monoclonal
Description	Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin s lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
Host	Mouse
Immunogen	Heavy chain of human IgM
Isotype	IgG1 Kappa
Positive Control	293T, Raji or hPBL cells. Tonsil or Spleen.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01871; P20769
Uniprot	510635
Gene Id	3507

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202181	3507-MSM1X-P1ABX	100µg	$393.20		Add to Cart

Anti-IgM (Immunoglobulin Mu Heavy Chain) Antibody BHA10202181

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