This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alteative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.
Host
Mouse
Immunogen
Purified human IGF-1 protein
Isotype
IgG1 Kappa
Positive Control
Pancreas or brain. Breast, Thyroid or Colon Cancers; IGF-1 recombinant protein
Reactivity
Human, Mouse, Rat, Rabbit
Recombinant
FALSE
Regulatory
RUO
Swissprot
P05019
Uniprot
160562
Gene Id
3479
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF
Description
In-vitro Neutralization of Biological Activity of IGF-1 . Optimal dilution for a specific application should be determined., FACS ; IF
Dilution
FACS
0.5-1μg/million cells in 0.1ml
IF
1-2μg/ml
Reviews of Anti-Insulin-like Growth Factor-1 (IGF-1) Antibody BHA10202089