Anti-IgA (Immunoglobulin Alpha Heavy Chain) Antibody BHA10202104

Mfr.No.	3493-MSM1-P1ABX
Alternative Names	A2m Marker ; Ig alpha 1 Chain C Region ; Ig alpha 2 Chain C Region ; IGHA1 ; IGHA2 ; Immunoglobulin Am1 ; Immunoglobulin Am2 ; Immunoglobulin Heavy Constant Alpha 1 ; Immunoglobulin Heavy Constant Alpha 2
Categories	Primary Antibodies
Cellular Localization	Cell Surface, Cytoplasmic (Secreted)
Chromosome Location	14q32.33
Clonality	Monoclonal
Description	This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with both IgA1 and IgA2 subclasses of Alpha heavy chain. It reacts with the third constant domain (CH3) of the alpha chain of IgA molecules. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.ĀIgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkinā€™s lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
Host	Mouse
Immunogen	Purified human IgA
Isotype	IgG1 Kappa
Positive Control	Daudi, 293T, Raji or hPBL cells. Tonsil or Spleen.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01876; P01877
Uniprot	699841
Gene Id	3493;3494

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	1-2μg/million cells in 0.1ml
IF	0.5-1.0μg/ml 30 min RT
IHC-F	0.5-1.0μg/ml 30 min RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202104	3493-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-IgA (Immunoglobulin Alpha Heavy Chain) Antibody BHA10202104

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