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Home / Primary Antibodies / IHC Antibodies

Anti-HLA-DQ (MHC II) Antibody BHA10201838

SKU : BHA10201838

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NeoBiotechnologies, Inc.

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Mfr.No.	3117-MSM1-P1ABX
Alternative Names	CELIAC1 ; DC 4 alpha chain Gluten sensitive enteropathy (celiac disease) (GSE) ; HLA Class II DQ ; HLA class II histocompatibility antigen DQ ; HLA class II histocompatibility antigen DQ(1) alpha chain ; HLA class II histocompatibility antigen DQ(3) alpha chain ; HLA DQA1 ; HLA DQB ; HLA DQB1 ; IDDM1
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	6p21.3
Clonality	Monoclonal
Description	Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.ĀThis MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.
Host	Mouse
Immunogen	T4-positive CTL clone HG-38
Isotype	IgG2a Kappa
Positive Control	Raji cells. Tonsil or lymph node
Reactivity	Human, Pig
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01908; P01909; P01920
Uniprot	550475
Gene Id	3117;3118;3119

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(No special pretreatment is required for IHC staining of formalin/paraffin tissues); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201838	3117-MSM1-P1ABX	100µg	$393.20		Add to Cart

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