Anti-Granzyme B Antibody BHA10201720

Mfr.No.	3002-RBP-P1ABX
Alternative Names	Cathepsin G-like 1 ; CCPI ; CGL1 ; CSPB ; CTLA-1 ; CTSGL1 ; Cytotoxic serine protease B ; Cytotoxic T lymphocyte associated serine esterase 1 ; Cytotoxic T-lymphocyte proteinase 2 ; Fragmentin-2
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	14q11.2
Clonality	Polyclonal
Description	Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'non-self' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkinā€™s Disease.
Host	Rabbit
Immunogen	Recombinant fragment (115 Amino acid residues; aa 73-187) of human Granzyme B protein
Isotype	IgG
Positive Control	A431 cells. Spleen or Hodgkin’s Lymphoma.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P10144
Uniprot	1051
Gene Id	3002

Buffer	200μg/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
WB	1-2μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201720	3002-RBP-P1ABX	100µg	$393.20		Add to Cart

Anti-Granzyme B Antibody BHA10201720

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