Anti-Heparan Sulfate Proteoglycan (Large) / Perlecan Antibody BHA10201993

Mfr.No.	3339-RTM1X-P1BX
Alternative Names	Heparan sulfate proteoglycan of basement membrane ; HSPG ; Hspg2 ; LG3 peptide ; Perlecan ; PLC ; SJS1
Categories	Primary Antibodies
Cellular Localization	Basement Membrane
Chromosome Location	1p36.1-p34
Clonality	Monoclonal
Description	This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Host	Rat
Immunogen	Murine EHS laminin preparation
Isotype	IgG2a Kappa
Positive Control	Breast carcinomas, squamous cell carcinomas.
Reactivity	Human, Monkey, Cow, Pig, Mouse, Fish
Recombinant	FALSE
Regulatory	RUO

Swissprot	P98160
Uniprot	562227
Gene Id	3339

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin/paraffin tissues Requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201993	3339-RTM1X-P1BX	100µg	$393.20		Add to Cart

Anti-Heparan Sulfate Proteoglycan (Large) / Perlecan Antibody BHA10201993

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