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Home / Primary Antibodies / Monoclonal Antibodies

Anti-HLA-B (MHC Class I) Antibody BHA10201812

SKU : BHA10201812

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NeoBiotechnologies, Inc.

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Mfr.No.	3106-MSM2-P1ABX
Alternative Names	HLA-B, HLAB, MHC Class I HLA heavy chain, Leukocyte antigen class I-B
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	6p21.3
Clonality	Monoclonal
Description	This MAb recognizes the HLA-B27 cell surface antigen on human cells. It may be used to HLA type human lymphocytes. Approximately 60% of patients with ankylosing spondylitis are HLA-B27 positive. This reagent can be used to help identify this HLA haplotype in human lymphocytes. Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind pep- tides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-B encodes a membrane anchored heavy chain, which hetero-dimerizes with a light chain (Ī �-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-B alleles. The HLA-B27 allele appears with increased frequency in uveitis patients.
Host	Mouse
Immunogen	Lymphocytes from an HLA-B27 patient
Isotype	IgM Kappa
Positive Control	Human peripheral blood lymphocytes, tonsil or lymph node
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01889
Uniprot	77961
Gene Id	3106

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF

Description

Optimal dilution for a specific application should be determined., FACS ; IF

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201812	3106-MSM2-P1ABX	100µg	$393.20		Add to Cart

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