Anti-IDH1 (Isocitrate Dehydrogenase) Antibody BHA10202044

Mfr.No.	3417-MSM2-P1ABX
Alternative Names	Cytosolic NADP-isocitrate dehydrogenase ; Epididymis luminal protein 216 ; Epididymis secretory protein Li 26 ; HEL-216 ; HEL-S-26 ; ICDH ; IDCD ; IDH1 ; IDP ; IDPC
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic, Nuclear
Chromosome Location	2q33.3
Clonality	Monoclonal
Description	It recognizes a 45kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming α-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of α-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.
Host	Mouse
Immunogen	Recombinant fragment (119 Amino acid residues around aa 281-414) of human IDH1 protein (exact sequence is proprietary)
Isotype	IgG1 Kappa
Positive Control	HepG2, HeLa, HT29 or MCF7 cells. Breast, Colon or Prostate Carcinoma.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	O75874 (Human)
Uniprot	593422 (Human)
Gene Id	3417 (Human)

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 or 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	0.5-1μg/ml
WB	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10202044	3417-MSM2-P1ABX	100µg	$393.20		Add to Cart

Anti-IDH1 (Isocitrate Dehydrogenase) Antibody BHA10202044

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