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Home / Primary Antibodies / Monoclonal Antibodies

Anti-GnRH-Receptor / LH-RH Receptor Antibody BHA10201581

SKU : BHA10201581

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NeoBiotechnologies, Inc.

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Mfr.No.	2798-MSM2-P1ABX
Alternative Names	GnRH receptor ; GnRH-R ; GNRHR1 ; gonadotropin-releasing hormone (type 1) receptor 1 ; GRHR ; HH7 ; leutinizing-releasing hormone receptor ; LHRHR ; LRHR ; luliberin receptor
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	4q21.2 (GNRHR); 2p16.3 (LHCGR) (Human)
Clonality	Monoclonal
Description	Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.
Host	Mouse
Immunogen	A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor.
Isotype	IgG1 Kappa
Positive Control	T47D cells. Pituitary gland, ovarian or breast cancers.
Reactivity	Human, Pig, Rabbit
Recombinant	FALSE
Regulatory	RUO

Swissprot	P30968; P22888
Uniprot	407587; 468490
Gene Id	2798;3973

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF

Description

Optimal dilution for a specific application should be determined., FACS ; IF

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	1-2μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201581	2798-MSM2-P1ABX	100µg	$393.20		Add to Cart

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