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Home / Primary Antibodies / Flow Cytometry (FACS)

Anti-ALK (Anaplastic Lymphoma Kinase) / CD246 Antibody BHA10201290

SKU : BHA10201290

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NeoBiotechnologies, Inc.

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Mfr.No.	238-MSM3-P0
Alternative Names	ALK Tyrosine Kinase Receptor ; ALK/NPM1 fusion gene ; Anaplastic lymphoma kinase Ki1 ; Anaplastic Lymphoma Kinase p80 ; anaplastic lymphoma receptor tyrosine kinase ; CD246 ; mutant anaplastic lymphoma kinase ; NBLST3 ; Tcrz ; TFG/ALK
Antigen	ALK (Anaplastic Lymphoma Kinase) / CD246
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic, Nuclear
Chromosome Location	2p23
Clonality	Monoclonal
Conjugate	Unconjugated
Description	The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene, NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.
Host	Mouse
Immunogen	Recombinant human ALK protein fragment (aa1360-1460) (exact sequence is proprietary)
Isotype	IgG1 Kappa
Positive Control	Anaplastic Large Cell Lymphoma
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q9UM73
Uniprot	654469
Gene Id	238

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	200µg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml

Applications

FACS, IF, WB

Description

Optimal dilution for a specific application should be determined., FACS ; IF ; WB

Dilution

FACS	0.5-1μg/million cells
IF	0.5-1μg/ml
WB	0.5-1μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201290	238-MSM3-P0	20µg	$204.67		Add to Cart
BHA10201290	238-MSM3-P0	100µg	$393.20		Add to Cart

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