JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Primary Antibodies / Monoclonal Antibodies

Anti-ALK (Anaplastic Lymphoma Kinase) / CD246 Antibody BHA10201292

SKU : BHA10201292

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

NeoBiotechnologies, Inc.

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	238-MSM3-P1ABX
Alternative Names	ALK Tyrosine Kinase Receptor ; ALK/NPM1 fusion gene ; Anaplastic lymphoma kinase Ki1 ; Anaplastic Lymphoma Kinase p80 ; anaplastic lymphoma receptor tyrosine kinase ; CD246 ; mutant anaplastic lymphoma kinase ; NBLST3 ; Tcrz ; TFG/ALK
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic, Nuclear
Chromosome Location	2p23
Clonality	Monoclonal
Description	The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene, NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.
Host	Mouse
Immunogen	Recombinant human ALK protein fragment (aa1360-1460) (exact sequence is proprietary)
Isotype	IgG1 Kappa
Positive Control	Anaplastic Large Cell Lymphoma
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q9UM73
Uniprot	654469
Gene Id	238

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB

Description

Optimal dilution for a specific application should be determined., FACS ; IF ; WB

Dilution

FACS	0.5-1μg/million cells
IF	0.5-1μg/ml
WB	0.5-1μg/ml

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHA10201292	238-MSM3-P1ABX	100µg	$393.20		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.