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Home / Primary Antibodies / Monoclonal Antibodies

Anti-FLI1 Antibody BHA10201121

SKU : BHA10201121

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NeoBiotechnologies, Inc.

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Mfr.No.	2313-MSM2-P1ABX
Alternative Names	ERGB transcription factor ; Ewing Sarcoma breakpoint region 2 (EWSR2) ; FLI1 ; FLI1 EWS fusion gene ; Friend leukemia integration 1 (FLI1) transcription factor ; Friend leukemia virus integration 1 ; Proto-oncogene Fli-1 ; SIC1 ; Transcription factor ERGB ; Viral integration region FLI1
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	11q24.1-q24.3
Clonality	Monoclonal
Description	Recognizes a protein of 51kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus.Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing s Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11;22)(q24;q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi s Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.
Host	Mouse
Immunogen	Recombinant fragment (aa 107-261) of human FLI1 protein (exact sequence is proprietary)
Isotype	IgG
Positive Control	THP1 and Raji cells. Tonsil, Ewing s sarcoma (EWS) and Angiosarcoma
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q01543
Uniprot	504281
Gene Id	2313

Buffer	200μg/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA at 1.0mg/ml

Applications

FACS, IF, WB

Description

Optimal dilution for a specific application should be determined., FACS ; IF ; WB

Dilution

FACS	0.5-1μg/million cells
IF	1-2μg/ml
WB	1-2μg/ml for 60 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201121	2313-MSM2-P1ABX	100µg	$393.20		Add to Cart

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