Anti-ER-beta1 (Estrogen Receptor beta-1) Antibody BHA10201031

Mfr.No.	2100-MSM2-P1ABX
Alternative Names	Erb ; ESR BETA ; ESR2 ; ESRB ; ESTRB ; estrogen nuclear receptor beta variant a ; estrogen nuclear receptor beta variant b ; estrogen receptor 2 (ER beta) ; estrogen receptor beta 4
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	14q23.2
Clonality	Monoclonal
Description	Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
Host	Mouse
Immunogen	C-terminus fragment of recombinant human estrogen receptor beta protein
Isotype	IgG2a
Positive Control	MCF-7 Cells. Ovarian, Breast, Bladder, Gastric or Salivary carcinoma
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q92731
Uniprot	660607
Gene Id	2100

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution