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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CD16 / Fc-gamma Receptor III Antibody BHA10201101

SKU : BHA10201101

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NeoBiotechnologies, Inc.

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Mfr.No.	2214-MSM5-P1ABX
Alternative Names	FcRIIIa ; FCR-10 ; FcRIII ; FCGRIII ; FcR-10 ; Fc fragment of IgG, low affinity IIIa, receptor for (CD16) ; neutrophil-specific antigen NA ; CD16a ; low affinity immunoglobulin gamma Fc region receptor III-A ; Fc-gamma RIIIa
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	1q23
Clonality	Monoclonal
Description	It recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
Host	Mouse
Immunogen	Human CD16 protein
Isotype	IgG1 Kappa
Positive Control	K-562 or U-937 cells. Lymph nodes and tonsils.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P08637
Uniprot	372679
Gene Id	2214

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF

Description

Optimal dilution for a specific application should be determined., FACS ; IF

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201101	2214-MSM5-P1ABX	100µg	$393.20		Add to Cart

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