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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Desmoglein-2 (DSG2) Antibody BHA10200823

SKU : BHA10200823

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NeoBiotechnologies, Inc.

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Mfr.No.	1829-MSM1-P1ABX
Alternative Names	ARVC10 ; ARVD10 ; Cadherin family member 5 ; CDHF5 ; CMD1BB ; Desmoglein-2 ; DSG2 ; HDGC ; Human Desmoglein Colon
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	18q12.1
Clonality	Monoclonal
Description	Recognizes a protein of 165kDa, identified as Desmoglein-2 (DSG2). This monoclonal antibody recognizes the extracellular domain of human desmoglein-2. Desmoglein-2 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Human Desmoglein-2 is a type I transmembrane glycoprotein of 1117 amino acid (aa) residues with a 23 aa signal peptide and a 25 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Instead of having the HAV adhesion motif found in type I cadherins, desmogleins have R/YAL as the adhesion motif on its amino-terminal cadherin repeat. The cytoplasmic tails of desmogleins interact with desmoplakins, plakoglobin and plakophilins. In turn, these proteins link the desmogleins with the intermediate filaments. Desmoglein-2 has been shown to be important in establishing cell-cell adhesion and function in epithelial cells. Desmoglein2 was originally identified in colon carcinoma and colon, and was named HDGC (human desmoglein colon).
Host	Mouse
Immunogen	Recombinant human full-length DSG2 protein
Isotype	IgG1 Kappa
Positive Control	A431, HepG2 or K562 cells. Heart or Colon
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q14126
Uniprot	412597
Gene Id	1829

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB

Description

Optimal dilution for a specific application should be determined., FACS ; IF ; WB

Dilution

FACS	0.5-1μg/million cells
IF	1-2μg/ml
WB	0.5-1.0μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200823	1829-MSM1-P1ABX	100µg	$393.20		Add to Cart

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