Anti-Desmin Antibody BHA10200698

Mfr.No.	1674-MSM1-P1ABX
Alternative Names	CMD1I ; CSM1 ; CSM2 ; DES ; Intermediate filament protein
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	2q35
Clonality	Monoclonal
Description	Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
Host	Mouse
Immunogen	Recombinant human full-length desmin protein
Isotype	IgG1 Kappa
Positive Control	SJRH30 Cells. Uterus or Leiomyosarcoma
Reactivity	Human, Mouse, Rat, Hamster, Chicken
Recombinant	FALSE
Regulatory	RUO

Swissprot	P17661
Uniprot	594952
Gene Id	1674

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

IF, FACS, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., IF ; FACS ; WB ; IHC-F

Dilution

IF	1-2μg/ml
FACS	0.5-1μg/million cells
WB	0.5-1μg/ml
IHC-F	1-2μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200698	1674-MSM1-P1ABX	100µg	$393.20		Add to Cart

Anti-Desmin Antibody BHA10200698

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