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Home / Primary Antibodies / Flow Cytometry (FACS)

Anti-Catenin, delta-1 (CTNND1) (pTyr96) Antibody BHA10200683

SKU : BHA10200683

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NeoBiotechnologies, Inc.

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Mfr.No.	1500-MSM1-P1ABX
Alternative Names	Cadherin-associated Src substrate (CAS) ; Catenin (cadherin associated protein) delta 1 ; Catenin delta-1 ; CTNND1 ; p120 catenin ; P120 CTN ; p120(cas) ; p120(ctn) ; P120CAS ; P120CTN
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	11q11
Clonality	Monoclonal
Description	The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.
Host	Mouse
Immunogen	Mouse p120 Catenin (pY96)
Isotype	IgG1 Kappa
Positive Control	Carcinoma
Reactivity	Human, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	O60716 (Human)
Uniprot	166011 (Human)
Gene Id	1500 (Human)

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF

Description

Optimal dilution for a specific application should be determined., FACS ; IF

Dilution

FACS	0.5-1μg/million cells
IF	1-2μg/ml

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200683	1500-MSM1-P1ABX	100µg	$393.20		Add to Cart

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