Anti-Alpha-1-Antichymotrypsin (SERPINA3) Antibody BHA10200492

Mfr.No.	12-MSM2-P1ABX
Alternative Names	SERPINA3 ; AACT ; ACT ; Alpha-1-antichymotrypsin ; Antichymotrypsin ; Cell growth-inhibiting gene 24/25 protein ; GIG24 ; GIG25 ; Growth inhibiting protein 24 ; Growth inhibiting protein 25
Antigen	Alpha-1-Antichymotrypsin (SERPINA3)
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	14q32.1
Clonality	Monoclonal
Conjugate	Unconjugated
Description	It recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). AACT is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of α 1-antitrypsin (AAT), with which it shares nucleic acid and protein sequence homology. Both are major acute phase reactants; their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACT antibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity.
Host	Mouse
Immunogen	Recombinant human Antichymotrypsin (AACT) protein fragment (aa49-187) (exact sequence is proprietary)
Isotype	IgG1
Positive Control	HeLa Cells. Tonsil, Pancreas or Histiocytoma.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P01011
Uniprot	534293; 710488
Gene Id	12

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, WB, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; WB ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	0.5-1μg/ml
WB	0.5-1.0μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200492	12-MSM2-P1ABX	100µg	$393.20		Add to Cart

Anti-Alpha-1-Antichymotrypsin (SERPINA3) Antibody BHA10200492

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