Beta-Granin ; CGA ; CHGA ; Chromogranin A Parathyroid Secretory Protein 1 ; ER-37 ; Pancreastatin ; Parastatin ; Parathyroid Secretory Protein 1 ; Pituitary Secretory Protein I ; SP-I
Categories
Primary Antibodies
Cellular Localization
Finely granular cytoplasmic
Chromosome Location
14q32.12
Clonality
Polyclonal
Description
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
Host
Rabbit
Immunogen
Recombinant human full-length Chromogranin A protein
Isotype
IgG Kappa
Positive Control
PC12 cells. Adrenal gland, bowel, parathyroid, pancreas, or pheochromocytoma.
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P10645
Uniprot
150793
Gene Id
1113
Buffer
200μg/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, IHC-F
Description
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes) ,Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F
Dilution
FACS
0.5-1μg/million cells
IF
1-2μg/ml
IHC-F
0.25-0.5μg/ml for 30 minutes at RT
No Description Available.
No Description Available.
Reviews of Anti-Chromogranin A / CHGA Antibody BHA10200471