C3 binding protein ; C3b/C4b receptor ; C3BR ; C4BR ; Complement Component (3b/4b) receptor 1 including Knops blood group system ; Complement receptor type 1 ; KN ; Knops blood group antigen
Categories
Primary Antibodies
Cellular Localization
Cell Surface
Chromosome Location
1q32.2
Clonality
Monoclonal
Description
Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This MAb is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma.
Host
Mouse
Immunogen
Intact human monocytes
Isotype
IgG1 Kappa
Positive Control
Follicular dendritic cells (FDC) in tonsil
Reactivity
Human, Baboon, Cynomolgus Monkey, Rhesus monkey
Recombinant
FALSE
Regulatory
RUO
Swissprot
P17927
Uniprot
334019
Gene Id
1378
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, IHC-F, IHC(af)
Description
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F ; IHC(af)