Anti-p57Kip2 (Mitotic Inhibitor/Suppressor Protein) Antibody BHA10200129

Mfr.No.	1028-MSM2-P0
Alternative Names	Beckwith Wiedemann syndrome (WBS) ; BWCR ; Cyclin dependent kinase inhibitor 1C (CDKN1C) ; Cyclin dependent kinase inhibitor p57 ; KIP2 ; p57 ; p57Kip2
Categories	Primary Antibodies
Cellular Localization	Nuclear
Chromosome Location	11p15.5
Clonality	Monoclonal
Description	Recognizes a protein of 57kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.
Host	Mouse
Immunogen	Recombinant human p57Kip2 protein
Isotype	IgG2b Kappa
Positive Control	LS174T, Raji, HT29, SK-BR3 cells. Colon or Prostate carcinomas.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO

Swissprot	P49918
Uniprot	106070
Gene Id	1028

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	200µg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells in 0.1ml
IF	0.5-1μg/ml
IHC-F	0.25-0.5μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10200129	1028-MSM2-P0	20µg	$204.67		Add to Cart
BHA10200129	1028-MSM2-P0	100µg	$393.20		Add to Cart

Anti-p57Kip2 (Mitotic Inhibitor/Suppressor Protein) Antibody BHA10200129

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