GC4 ; cap43 ; cmt4d ; Differentiation-related gene 1 protein ; DRG-1 ; Hmsnl ; Human mRNA for RTP complete cds ; N-myc downstream-regulated gene 1 protein ; NDRG1 ; Nickel-specific induction protein Cap43
Categories
Primary Antibodies
Cellular Localization
Cell Surface, Cytoplasmic
Chromosome Location
8q24.3
Clonality
Monoclonal
Description
It recognizes a protein of 43kDa, which is identified as N-myc downstream-regulated gene 1 protein (NDRG1). The NDRG) family is comprised of four members, NDRG1, NDRG2, NDRG3 and NDRG4, which share 57-65% homology. The NDRG1 gene is ubiquitously expressed, but it is expressed most prominently in placental membranes and prostate, kidney, small intestine and ovary tissue. NDRG1 is a direct transcriptional target gene of p53 to mediated cell death and apoptosis. NDRG1 gene expression is induced by several compounds, including nickel, and produces a protein involved in stress responses, hormone responses, cell growth and differentiation. The reduced expression of NDRG1 has been found to be associated with tumor metastasis in a variety of tumors, including cancers of the breast, colon, prostate, oral cavity and oropharynx. Reportedly, overexpression of NDRG1 in hepatocellular carcinoma is an indicator of tumor aggressiveness.
Host
Mouse
Immunogen
Recombinant fragment of human NDRG1 fragment (aa162-283) (exact sequence is proprietary)
Isotype
IgG3
Positive Control
HeLa Cells. Prostrate or Renal Carcinoma.
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
Q92597
Uniprot
372914
Gene Id
10397
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, WB
Description
Optimal dilution for a specific application should be determined., FACS ; IF ; WB